| 别名 | COX2; COX-2; Cyclooxygenase 2; PGH2; PGHS2; PHS2; TIS10; PTGS2; |
| 基因名称 | Cox2 |
| 蛋白名称 | Cox2 |
| 推荐应用 | |
| 反应物种 | Human Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5743 |
| Human Swissprot No. | P35354 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50 |
| 参考分子量 | MW(Observed):75kD |
| 预测分子量 | MW(Calculated):69kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. |
| 细胞定位 | Cytoplasm |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm |
| 组织表达 | Inflammatory tissues, Kidney, Lung, Colon cancer, Lung cancer, Breast cancer. |
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