| 别名 | EGLN1; C1orf12; ECYT3; HIFPH2; HPH2; PHD2; SM-20; SM20; ZMYND6; |
| 基因名称 | PHD2 / prolyl hydroxylase |
| 蛋白名称 | PHD2 / prolyl hydroxylase |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 54583 |
| Human Swissprot No. | Q9GZT9 |
| Mouse Gene ID | 112405 |
| Mouse Swissprot No. | Q91YE3 |
| Rat Swissprot No. | P59722 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):46kD |
| 预测分子量 | MW(Calculated):46kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| 细胞定位 | Cytoplasm, Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Nucleus. |
| 组织表达 | Liver, Kidney, Heart, Hepatocellular carcinoma, Renal cell carcinoma, Lung cancer. |
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