| 别名 | DNA topoisomerase 1; DNA topoisomerase I; TOP1; TOPI; topoisomerase I; type I DNA |
| 基因名称 | TOP1 |
| 蛋白名称 | TOP1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 7150 |
| Human Swissprot No. | P11387 |
| Mouse Gene ID | 21969 |
| Mouse Swissprot No. | Q04750 |
| Rat Gene ID | 64550 |
| Rat Swissprot No. | Q9WUL0 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:1000~1:2000 |
| 参考分子量 | MW(Observed):91kD |
| 预测分子量 | MW(Calculated):91kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. |
| 细胞定位 | Nucleus, nucleoplasm. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus, nucleoplasm. |
| 组织表达 | Widely expressed (Testis, Thymus, Bone marrow) |
周一至周日 8:00-18:00
