| 别名 | Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; ALPL; |
| 基因名称 | Alkaline Phosphatase |
| 蛋白名称 | Alkaline Phosphatase |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 249 |
| Human Swissprot No. | P05186 |
| Mouse Gene ID | 11647 |
| Mouse Swissprot No. | P09242 |
| Rat Gene ID | 25586 |
| Rat Swissprot No. | P08289 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:5000~1:10000 IHC 1:50~1:200 ICC/IF 1:50~1:100 IP 1:50 FC 1:50 |
| 参考分子量 | MW(Observed):57kD |
| 预测分子量 | MW(Calculated):57kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. |
| 细胞定位 | Cell membrane ; Lipid-anchor , GPI-anchor . Extracellular vesicle membrane ; Lipid-anchor , GPI-anchor . Mitochondrion membrane ; Lipid-anchor , GPI-anchor . Mitochondrion intermembrane space . Localizes to special class of extracellular vesicles , named matrix vesicles (MVs) , which are released by osteogenic cells. Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane ; Lipid-anchor , GPI-anchor . Extracellular vesicle membrane ; Lipid-anchor , GPI-anchor . Mitochondrion membrane ; Lipid-anchor , GPI-anchor . Mitochondrion intermembrane space . Localizes to special class of extracellular vesicles , named matrix vesicles (MVs) , which are released by osteogenic cells. Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space. |
| 组织表达 | Bone, Liver, Kidney, Osteosarcoma, Hepatocellular carcinoma, Renal cell carcinoma. |
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