| 别名 | GRB1; P85A; PI3-kinase p85-alpha; PI3K; PI3K p85-alpha; ptdIns-3-kinase p85-alpha; |
| 基因名称 | PI 3 Kinase p85 alpha |
| 蛋白名称 | PI 3 Kinase p85 alpha |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5295 |
| Human Swissprot No. | P27986 |
| Mouse Gene ID | 18708 |
| Mouse Swissprot No. | P26450 |
| Rat Gene ID | 25513 |
| Rat Swissprot No. | Q63787 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):85kD |
| 预测分子量 | MW(Calculated):84kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. |
| 细胞定位 | Cytoplasm, membrane, nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, membrane, nucleus. |
| 组织表达 | Widely expressed (Liver, Kidney, Lung) |
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