| 别名 | DAZH, DAZL1, DAZLA, DAZ-like autosomal, Deleted in azoospermia-like |
| 基因名称 | DAZL |
| 蛋白名称 | DAZL |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 1618 |
| Human Swissprot No. | Q92904 |
| Mouse Gene ID | 13164 |
| Mouse Swissprot No. | Q64368 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:4000;IF 1:50-1:200;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):38kD |
| 预测分子量 | MW(Calculated):33kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010], |
| 细胞定位 | Cytoplasm . Nucleus . Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. . |
| 功能 | Disease:Defects in DAZL may be a cause of infertility due to severe oligozoospermia (AZ) and non obstructive azoospermia.,Domain:The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.,Function:RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts.,similarity:Belongs to the RRM DAZ family.,similarity:Contains 1 DAZ-like domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Predominantly cytoplasmic (By similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.,subunit:Homodimer and heterodimer (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.,tissue specificity:Testis specific., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm . Nucleus . Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. . |
| 组织表达 | Testis specific. |
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