| 别名 | JUP;CTNNG;DP3;Junction plakoglobin;Catenin gamma;Desmoplakin III;Desmoplakin-3 |
| 基因名称 | Catenin-γ |
| 蛋白名称 | Junction plakoglobin |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 3728 |
| Human Swissprot No. | P14923 |
| Mouse Gene ID | 16480 |
| Mouse Swissprot No. | Q02257 |
| Rat Gene ID | 81679 |
| Rat Swissprot No. | Q6P0K8 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:4000;IF 1:50-1:200;ELISA 1:5000-1:20000; |
| 参考分子量 | MW(Observed):82kD |
| 预测分子量 | MW(Calculated):82kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form. |
| 功能 | Disease:Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,Disease:Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.,Function:Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.,sequence Caution:Translation N-terminally shortened.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subcellular location:Cytoplasmic in a soluble and membrane-associated form.,subunit:Homodimer. Interacts with MUC1., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form. |
| 组织表达 | Cervix carcinoma,Epidermal carcinoma,Epithelium,Leukocyte,Lung,Lung carcinoma,Place |
| 研究领域 | >>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Gastric cancer;>>Arrhythmogenic right ventricular cardiomyopathy |
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