| 别名 | Frequently rearranged in advanced T-cell lymphomas 1、FRAT-1、GSK3 binding protein FRAT1、proto-oncogene FRAT1 |
| 基因名称 | FRAT1 |
| 蛋白名称 | Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 10023 |
| Human Swissprot No. | Q92837 |
| Mouse Swissprot No. | P70339 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500;IP 1:50-1:200;FC 1:100-1:500; |
| 参考分子量 | MW(Observed):31kDa |
| 预测分子量 | MW(Calculated):31kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008], |
| 细胞定位 | Cytoplasm. |
| 功能 | Function:Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.,PTM:Phosphorylated.,similarity:Belongs to the GSK-3-binding protein family.,subunit:Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm. |
| 组织表达 | Lung,Testis, |
| 研究领域 | >>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathways in cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer |
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