| 别名 | Alpha-ketoglutarate receptor 1、GPR99、GPR80、P2RY15、P2Y15、AKGR、CysLTR3、2-oxoglutarate receptor 1 |
| 基因名称 | OXGR1 |
| 蛋白名称 | 2-oxoglutarate receptor 1 (Alpha-ketoglutarate receptor 1) (G-protein coupled receptor 80) (G-protein coupled receptor 99) (P2Y purinoceptor 15) (P2Y15) (P2Y-like GPCR) (P2Y-like nucleotide receptor) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 27199 |
| Human Swissprot No. | Q96P68 |
| Mouse Swissprot No. | Q6IYF8 |
| Rat Swissprot No. | Q6Y1R5 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500;IP 1:50-1:200;FC 1:100-1:500; |
| 参考分子量 | MW(Observed):37kDa |
| 预测分子量 | MW(Calculated):37kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016], |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 功能 | Caution:Was originally (Ref.5) thought to be a P2Y receptor.,Function:Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织表达 | Detected in kidney and, to a lower extent, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons. |
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