| 别名 | LYPD3;C4.4A;UNQ491/PRO1007;Ly6/PLAUR domain-containing protein 3 ;GPI-anchored metastasis-associated protein C4.4A homolog;Matrigel-induced gene C4 protein;MIG-C4; |
| 基因名称 | LYPD3 |
| 蛋白名称 | Ly6/PLAUR domain-containing protein 3;GPI-anchored metastasis-associated protein C4.4A homolog;Matrigel-induced gene C4 protein;MIG-C4; |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 27076 |
| Human Swissprot No. | O95274 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500； |
| 参考分子量 | MW(Observed):38kD |
| 预测分子量 | MW(Calculated):38kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Predicted to enable laminin binding activity. Involved in negative regulation of smooth muscle cell apoptotic process. Located in extracellular space. |
| 细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. |
| 功能 | Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression. {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:11245483, ECO:0000269|PubMed:12592373, ECO:0000269|PubMed:15012588}. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. |
| 组织表达 | Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:12592373, ECO:0000269|PubMed:15012588}. |
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