货号：BSCY0795
TAF1C;TATA box-binding protein-associated factor RNA polymerase I subunit C ;RNA polymerase I-specific TBP-associated factor 110 kDa;TAFI110;TATA box-binding protein-associated factor 1C;TBP-associated factor 1C;Transcription initiation factor SL1/TIF-IB
| 别名 | TAF1C;TATA box-binding protein-associated factor RNA polymerase I subunit C ;RNA polymerase I-specific TBP-associated factor 110 kDa;TAFI110;TATA box-binding protein-associated factor 1C;TBP-associated factor 1C;Transcription initiation factor SL1/TIF-IB |
| 基因名称 | TAF1C |
| 蛋白名称 | TATA box-binding protein-associated factor RNA polymerase I subunit C;RNA polymerase I-specific TBP-associated factor 110 kDa;TAFI110;TATA box-binding protein-associated factor 1C;TBP-associated factor 1C;Transcription initiation factor SL1/TIF-IB subunit |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 9013 |
| Human Swissprot No. | Q15572 |
| Mouse Gene ID | 21341 |
| Mouse Swissprot No. | Q6PDZ2 |
| Rat Gene ID | 361420 |
| Rat Swissprot No. | Q6P773 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500； |
| 参考分子量 | MW(Observed):96kD |
| 预测分子量 | MW(Calculated):96kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex , known as SL1 , binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
| 细胞定位 | Nucleus, nucleolus. |
| 功能 | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:15970593}. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus, nucleolus. |
| 组织表达 | Testis, Thymus, Bone marrow, Lung cancer, Colon cancer, Breast cancer |
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