| 别名 | PPIL1;CYPL1;CGI-124;UNQ2425/PRO4984;Peptidyl-prolyl cis-trans isomerase-like 1 ;PPIase;Rotamase PPIL1; |
| 基因名称 | PPIL1 |
| 蛋白名称 | Peptidyl-prolyl cis-trans isomerase-like 1;PPIase;Rotamase PPIL1; |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 51645 |
| Human Swissprot No. | Q5TDC9 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500； |
| 参考分子量 | MW(Observed):19kD |
| 预测分子量 | MW(Calculated):19kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases) . The cyclophilins are a highly conserved , ubiquitous family , members of which play an important role in protein folding , immunosuppression by cyclosporin A , and infection of HIV-1 virions. Based on similarity to other PPIases , this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| 细胞定位 | Nucleus. |
| 功能 | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:33220177). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16595688, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:33220177}. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus. |
| 组织表达 | Ubiquitous, with the most abundant expression in heart and skeletal muscle. |
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