| 别名 | ACTR1B;CTRN2;Beta-centractin ;Actin-related protein 1B;ARP1B; |
| 基因名称 | ACTY |
| 蛋白名称 | Beta-centractin;Actin-related protein 1B;ARP1B; |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 10120 |
| Human Swissprot No. | P42025 |
| Mouse Gene ID | 226977 |
| Mouse Swissprot No. | Q8R5C5 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500； |
| 参考分子量 | MW(Observed):41kD |
| 预测分子量 | MW(Calculated):41kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008], |
| 细胞定位 | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
| 功能 | Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
| 组织表达 | Brain, Skeletal muscle, Heart, Neuroblastoma, Lung cancer, Colon cancer |
| 研究领域 | >>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection |
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