| 别名 | SLC2A1;GLUT1;Solute carrier family 2;facilitated glucose transporter member 1;Glucose transporter type 1, erythrocyte/brain;GLUT-1;HepG2 glucose transporter |
| 基因名称 | GLUT-1 |
| 蛋白名称 | Solute carrier family 2 facilitated glucose transporter member 1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 6513 |
| Human Swissprot No. | P11166 |
| Mouse Gene ID | 20525 |
| Mouse Swissprot No. | P17809 |
| Rat Gene ID | 24778 |
| Rat Swissprot No. | P11167 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:200-1:1000;WB 1:5000-1:20000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):50-300kD |
| 预测分子量 | MW(Calculated):54kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013], |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . Melanosome . Photoreceptor inner segment . Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). . |
| 功能 | Disease:Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome [MIM:606777]; also called blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.,Disease:Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.,Function:Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.,online information:GLUT1 entry,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.,subcellular location:Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Expressed at variable levels in many human tissues., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . Melanosome . Photoreceptor inner segment . Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). . |
| 组织表达 | Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues. |
| 研究领域 | >>HIF-1 signaling pathway;>>Insulin secretion;>>Thyroid hormone signaling pathway;>>Adipocytokine signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Bile secretion;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Renal cell carcinoma;>>Central carbon metabolism in cancer;>>Diabetic cardiomyopathy |
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