货号：BSCY0561
MYL9;MLC2;MRLC1;MYRL2;Myosin regulatory light polypeptide 9;20 kDa myosin light chain;LC20;MLC-2C;Myosin RLC;Myosin regulatory light chain 2;smooth muscle isoform;Myosin regulatory light chain 9;Myosin regulatory light chain MRL
| 别名 | MYL9;MLC2;MRLC1;MYRL2;Myosin regulatory light polypeptide 9;20 kDa myosin light chain;LC20;MLC-2C;Myosin RLC;Myosin regulatory light chain 2;smooth muscle isoform;Myosin regulatory light chain 9;Myosin regulatory light chain MRL |
| 基因名称 | Myosin Light Chain 2 |
| 蛋白名称 | Myosin regulatory light polypeptide 9 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 10398;10627 |
| Human Swissprot No. | P24844 |
| Mouse Gene ID | 98932 |
| Mouse Swissprot No. | Q9CQ19 |
| Rat Gene ID | 296313 |
| Rat Swissprot No. | Q64122 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):20kD |
| 预测分子量 | MW(Calculated):20kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. . |
| 功能 | Function:Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.,miscellaneous:This chain binds calcium.,PTM:Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains.,tissue specificity:Smooth muscle tissues and in some, but not all, nonmuscle cells., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. . |
| 组织表达 | Smooth muscle tissues and in some, but not all, nonmuscle cells. |
| 研究领域 | >>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Vascular smooth muscle contraction;>>Axon guidance;>>Focal adhesion;>>Tight junction;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Oxytocin signaling pathway;>>Shigellosis;>>Salmonella infection |
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