| 别名 | ALDH1A1;ALDC;ALDH1;PUMB1;Retinal dehydrogenase 1;RALDH 1;RalDH1;ALDH-E1;ALHDII;Aldehyde dehydrogenase family 1 member A1;Aldehyde dehydrogenase, cytosolic |
| 基因名称 | ALDH1A1 |
| 蛋白名称 | Retinal dehydrogenase 1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 216 |
| Human Swissprot No. | P00352 |
| Mouse Swissprot No. | P24549 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:5000；ELISA 1:5000-1:20000 |
| 参考分子量 | MW(Observed):55kD |
| 预测分子量 | MW(Calculated):55kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011], |
| 细胞定位 | Cytoplasm, cytosol . Cell projection, axon . |
| 功能 | Catalytic activity:Retinal + NAD(+) + H(2)O = retinoate + NADH.,Function:Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, cytosol . Cell projection, axon . |
| 组织表达 | Expressed by erythrocytes (at protein level). |
| 研究领域 | >>Retinol metabolism;>>Metabolic pathways |
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