货号：BSCY0417
PP2A A;PP2A alpha;PP2A B;PP2A beta;PP2A-alpha;PP2A-beta;PP2AA_HUMAN;PP2Aalpha;PP2AB_HUMAN;PP2Abeta;PP2Ac;PP2CA;PP2Calpha;PP2CB;PPP2CA;PPP2CB;Protein phosphatase 2 catalytic subunit alpha isoform;Protein phosphatase 2 catalytic subunit beta isoform;Protein
| 别名 | PP2A A;PP2A alpha;PP2A B;PP2A beta;PP2A-alpha;PP2A-beta;PP2AA_HUMAN;PP2Aalpha;PP2AB_HUMAN;PP2Abeta;PP2Ac;PP2CA;PP2Calpha;PP2CB;PPP2CA;PPP2CB;Protein phosphatase 2 catalytic subunit alpha isoform;Protein phosphatase 2 catalytic subunit beta isoform;Protein |
| 基因名称 | PPP2CA;PPP2CB |
| 蛋白名称 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PP2A-beta;PP2A-alpha;Replication protein C;RP-C; |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5515;5516 |
| Human Swissprot No. | P67775;P62714 |
| Mouse Gene ID | 19052;19053 |
| Mouse Swissprot No. | P63330;P62715 |
| Rat Gene ID | 24672;24673 |
| Rat Swissprot No. | P63331;P62716 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):36kD |
| 预测分子量 | MW(Calculated):36kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm |
| 组织表达 | Fibroblast,Liver,Lung,Placenta,Testis,Uterus,baseline |
| 研究领域 | >>mRNA surveillance pathway;>>Sphingolipid signaling pathway;>>Oocyte meiosis;>>Autophagy - other;>>Autophagy - animal;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Tight junction;>>Dopaminergic synapse;>>Long-term depression;>>Chagas disease;>>Hepatitis C;>>Human papillomavirus infection |
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