| 别名 | P4HB ERBA2L PDI PDIA1 PO4DB |
| 基因名称 | P4HB |
| 蛋白名称 | Protein disulfide-isomerase (PDI) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5034 |
| Human Swissprot No. | P07237 |
| Mouse Gene ID | 18453 |
| Mouse Swissprot No. | P09103 |
| Rat Gene ID | 25506 |
| Rat Swissprot No. | P04785 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):57kD |
| 预测分子量 | MW(Calculated):57kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes the beta subunit of prolyl 4-hydroxylase , a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits , this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation , breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner , its ability to bind thyroid hormone , its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide , and its function as a subunit of the microsomal triglyceride transfer protein complex. |
| 细胞定位 | Endoplasmic reticulum |
| 功能 | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Endoplasmic reticulum |
| 组织表达 | Liver, Pancreas, Heart, Brain, Hepatocellular carcinoma, Pancreatic cancer, Colon cancer |
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