| 别名 | FASN;FAS;Fatty acid synthase |
| 基因名称 | FASN |
| 蛋白名称 | Fatty acid synthase |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 2194 |
| Human Swissprot No. | P49327 |
| Mouse Swissprot No. | P19096 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:500-1:2000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):273kD |
| 预测分子量 | MW(Calculated):273kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | Catalytic activity:(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.,Catalytic activity:(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] = hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O.,Catalytic activity:Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].,Catalytic activity:Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).,Catalytic activity:Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].,Catalytic activity:Acyl-[acyl-carrier-protein] + NADP(+) = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH.,Catalytic activity:Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].,Catalytic activity:Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.,Function:Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.,miscellaneous:The relatively low beta-ketoacyl synthase activity may be attributable to the low 4'-phosphopantetheine content of the protein.,sequence Caution:Several sequencing errors.,similarity:Contains 1 acyl carrier domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer which is arranged in a head to tail fashion.,tissue specificity:Ubiquitous. Prominent expression in brain, lung, and liver., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm |
| 组织表达 | Ubiquitous. Prominent expression in brain, lung, liver and mammary gland. |
| 研究领域 | >>Fatty acid biosynthesis;>>Metabolic pathways;>>Fatty acid metabolism;>>AMPK signaling pathway;>>Insulin signaling pathway;>>Alcoholic liver disease |
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