| 别名 | High mobility group protein B1 (High mobility group protein 1) (HMG-1) |
| 基因名称 | HMGB1 |
| 蛋白名称 | High mobility group protein B1 (High mobility group protein 1) (HMG-1) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 3146 |
| Human Swissprot No. | P09429 |
| Mouse Gene ID | 100862258 |
| Mouse Swissprot No. | P63158 |
| Rat Gene ID | 25459 |
| Rat Swissprot No. | P63159 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:2000-1:10000;WB 1:5000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):25kD |
| 预测分子量 | MW(Calculated):25kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | high mobility group box 1(HMGB1) Homo sapiens This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015], |
| 细胞定位 | Nucleus |
| 功能 | Function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus |
| 组织表达 | Ubiquitous. Expressed in platelets (PubMed:11154118). |
| 研究领域 | >>Base excision repair;>>Autophagy - animal;>>Necroptosis;>>Neutrophil extracellular trap formation |
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