| 别名 | Long-chain-fatty-acid--CoA ligase 4;Long-chain acyl-CoA synthetase 4;LACS 4; |
| 基因名称 | ACSL4 |
| 蛋白名称 | ACSL4 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 2182 |
| Human Swissprot No. | O60488 |
| Mouse Gene ID | 50790 |
| Mouse Swissprot No. | Q9QUJ7 |
| Rat Gene ID | 113976 |
| Rat Swissprot No. | O35547 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:5000；ELISA 1:5000-1:20000 |
| 参考分子量 | MW(Observed):78kD |
| 预测分子量 | MW(Calculated):78kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity , subcellular localization , and tissue distribution , all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters , and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. |
| 细胞定位 | Membrane |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane |
| 组织表达 | Liver, Kidney, Heart, Skeletal muscle, Hepatocellular carcinoma, Colon cancer, Breast cancer |
| 研究领域 | >>Fatty acid biosynthesis;>>Fatty acid degradation;>>Metabolic pathways;>>Fatty acid metabolism;>>PPAR signaling pathway;>>Peroxisome;>>Ferroptosis;>>Thermogenesis;>>Adipocytokine signaling pathway |
周一至周日 8:00-18:00
