| 别名 | MIF;GLIF;MMIF;Macrophage migration inhibitory factor;MIF;Glycosylation-inhibiting factor;GIF;L-dopachrome isomerase;L-dopachrome tautomerase;Phenylpyruvate tautomerase |
| 基因名称 | MIF |
| 蛋白名称 | Macrophage migration inhibitory factor |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 4282 |
| Human Swissprot No. | P14174 |
| Mouse Gene ID | 17319 |
| Mouse Swissprot No. | P34884 |
| Rat Gene ID | 81683 |
| Rat Swissprot No. | P30904 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:3000-1:10000;WB 1:1000-1:2500;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):13kD |
| 预测分子量 | MW(Calculated):13kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | Catalytic activity:Keto-phenylpyruvate = enol-phenylpyruvate.,Disease:Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,Function:The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase.,similarity:Belongs to the MIF family.,subunit:Homotrimer. Interacts with COPS5 and BNIPL., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm |
| 组织表达 | Brain,Lens,Liver,Lung,Platelet,Skin |
| 研究领域 | >>Tyrosine metabolism;>>Phenylalanine metabolism;>>Metabolic pathways |
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