| 别名 | RPS6;OK/SW-cl.2;40S ribosomal protein S6;Phosphoprotein NP33 |
| 基因名称 | RPS6 |
| 蛋白名称 | 40S ribosomal protein S6 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 6194 |
| Human Swissprot No. | P62753 |
| Mouse Gene ID | 20104 |
| Mouse Swissprot No. | P62754 |
| Rat Gene ID | 29304 |
| Rat Swissprot No. | P62755 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:1000-1:4000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):35kD |
| 预测分子量 | MW(Calculated):29kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed |
| 细胞定位 | nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,ribosome,polysome,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,dendrite,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granula |
| 功能 | Function:May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.,PTM:Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.,similarity:Belongs to the ribosomal protein S6e family., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,ribosome,polysome,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,dendrite,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granula |
| 组织表达 | Brain,Colon,Colon adenocarcinoma,Epithelium,Muscle,Ovary,Pancreas,Placenta,Skin,Tes |
| 研究领域 | >>EGFR tyrosine kinase inhibitor resistance;>>Ribosome;>>HIF-1 signaling pathway;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>Apelin signaling pathway;>>Thermogenesis;>>Insulin signaling pathway;>>Coronavirus disease - COVID-19;>>Proteoglycans in cancer |
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