| 别名 | TNNI3;TNNC1;Troponin I; cardiac muscle;Cardiac troponin I |
| 基因名称 | TNNI3 |
| 蛋白名称 | Troponin I cardiac muscle |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 7137 |
| Human Swissprot No. | P19429 |
| Mouse Gene ID | 21954 |
| Mouse Swissprot No. | P48787 |
| Rat Gene ID | 29248 |
| Rat Swissprot No. | P23693 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:5000；ELISA 1:5000-1:20000 |
| 参考分子量 | MW(Observed):28kD |
| 预测分子量 | MW(Calculated):24kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that formThe troponin complex ofThe thin filaments of striated muscle. TnI isThe inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation.The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodesThe TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | Disease:Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,Disease:Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:191044]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,Disease:Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.,Function:Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.,similarity:Belongs to the troponin I family.,subunit:Binds to actin and tropomyosin. Interacts with TRIM63., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm |
| 组织表达 | Heart,Heart muscle,PCR rescued clones, |
| 研究领域 | >>cAMP signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Hypertrophic cardiomyopathy;>>Dilated cardiomyopathy;>>Diabetic cardiomyopathy |
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