| 别名 | FOXP3;IPEX;JM2;Forkhead box protein P3;Scurfin |
| 基因名称 | FOXP3 |
| 蛋白名称 | Forkhead box protein P3 |
| 推荐应用 | |
| 反应物种 | Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 50943 |
| Human Swissprot No. | Q9BZS1 |
| Mouse Gene ID | 20371 |
| Mouse Swissprot No. | Q99JB6 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500;ELISA 1:5000-1:20000;IP 1:50-1:200, |
| 参考分子量 | MW(Observed):47kD |
| 预测分子量 | MW(Calculated):47kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus |
| 功能 | Disease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,Function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus |
| 组织表达 | Thymus, Tonsil, Lymph node, Breast carcinoma, Lung cancer, Colorectal carcinoma, Melanoma |
| 研究领域 | >>Th17 cell differentiation;>>Inflammatory bowel disease |
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