| 别名 | Connective tissue growth factor;CCN family member 2;Hypertrophic chondrocyte-specific protein 24;Insulin-like growth factor-binding protein 8;IBP-8;IGF-binding protein 8;IGFBP-8; |
| 基因名称 | CTGF |
| 蛋白名称 | Connective tissue growth factor (CCN family member 2) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 1490 |
| Human Swissprot No. | P29279 |
| Mouse Gene ID | 14219 |
| Mouse Swissprot No. | P29268 |
| Rat Swissprot No. | Q9R1E9 |
| 特异性 | endogenous |
| 稀释度 | WB 1:500-2000；ELISA 1:5000-20000 |
| 参考分子量 | MW(Observed):38kD |
| 预测分子量 | MW(Calculated):38kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009], |
| 细胞定位 | Secreted |
| 功能 | Function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Secreted |
| 组织表达 | Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. |
| 研究领域 | >>Apelin signaling pathway;>>Hippo signaling pathway |
周一至周日 8:00-18:00
