| 别名 | ATP5B ATPMB ATPSB |
| 基因名称 | ATP5F1B |
| 蛋白名称 | ATP synthase subunit beta, mitochondrial (EC 3.6.3.14) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 506 |
| Human Swissprot No. | P06576 |
| Mouse Gene ID | 11947 |
| Mouse Swissprot No. | P56480 |
| Rat Gene ID | 171374 |
| Rat Swissprot No. | P10719 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:200-1:1000;WB 1:1000-1:2500;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200, |
| 参考分子量 | MW(Observed):52kD |
| 预测分子量 | MW(Calculated):57kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis , utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core , F1 , and the membrane-spanning component , Fo , comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha , beta , gamma , delta , and epsilon) assembled with a stoichiometry of 3 alpha , 3 beta , and a single representative of the other 3. The proton channel consists of three main subunits (a , b , c) . This gene encodes the beta subunit of the catalytic core. |
| 细胞定位 | Mitochondrion inner membrane |
| 功能 | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Mitochondrion inner membrane |
| 组织表达 | Heart, Skeletal muscle, Liver, Kidney, Hepatocellular carcinoma, Colon cancer, Lung cancer |
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