| 别名 | CDC37;CDC37A;Hsp90 co-chaperone Cdc37;Hsp90 chaperone protein kinase-targeting subunit;p50Cdc37 |
| 基因名称 | CDC37 |
| 蛋白名称 | Hsp90 co-chaperone Cdc37 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 11140 |
| Human Swissprot No. | Q16543 |
| Mouse Gene ID | 12539 |
| Mouse Swissprot No. | Q61081 |
| Rat Gene ID | 114562 |
| Rat Swissprot No. | Q63692 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:400-1000;WB 1:1000-1:2500;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| 参考分子量 | MW(Observed):44kD |
| 预测分子量 | MW(Calculated):44kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | Function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cytoplasm |
| 组织表达 | Lymph,Placenta, |
| 研究领域 | >>PI3K-Akt signaling pathway |
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