| 别名 | ACTB;Actin;cytoplasmic 1;Beta-actin;Actin β;β-Actin;Beta actin;B actin;actin Beta; |
| 基因名称 | ACTB |
| 蛋白名称 | Actin cytoplasmic 1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 60 |
| Human Swissprot No. | P60709 |
| 特异性 | endogenous |
| 稀释度 | WB 1:500-2000;ELISA 1:20000 |
| 参考分子量 | MW(Observed):42kD |
| 预测分子量 | MW(Calculated):42kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm, cytoskeleton. |
| 功能 | Disease:Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction , often leading to abnormal postures. DYTJ patients manifest progressive , generalized , dopa-unresponsive dystonia , developmental malformations and sensory hearing loss. ,Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ,miscellaneous:In vertebrates 3 main groups of actin isoforms , alpha , beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. ,similarity:Belongs to the actin family. ,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Component of the BAF complex , which includes at least actin (ACTB) , ARID1A , ARID1B/BAF250 , SMARCA2 , SMARCA4/BRG1 , ACTL6A/BAF53 , ACTL6B/BAF53B , SMARCE1/BAF57 SMARCC1/BAF155 , SMARCC2/BAF170 , SMARCB1/SNF5/INI1 , and one or more of SMARCD1/BAF60A , SMARCD2/BAF60B , or SMARCD3/BAF60C. In muscle cells , the BAF complex also contains DPF3. Found in a complex with XPO6 , Ran , ACTB and PFN1. Interacts with XPO6. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, cytoskeleton. |
| 组织表达 | Widely expressed |
周一至周日 8:00-18:00
