| 别名 | IKBKE;IKKE;IKKI;KIAA0151;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;I-kappa-B kinase epsilon;IKK-E;IKK-epsilon;IkBKE;Inducible I kappa-B kinase;IKK-i |
| 基因名称 | IKBKE |
| 蛋白名称 | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q14164 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 81kDa |
| 预测分子量 | 81kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al. , 2009 [PubMed 19481526]) .[supplied by OMIM , Oct 2009] , |
| 细胞定位 | Cytoplasm . Nucleus. Nucleus , PML body . Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669) . Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218) . . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm . Nucleus. Nucleus , PML body . Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669) . Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218) . . |
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