货号：GZ9811
CD40LG;CD40L;TNFSF5;TRAP;CD40 ligand;CD40-L;T-cell antigen Gp39;TNF-related activation protein;TRAP;Tumor necrosis factor ligand superfamily member 5;CD antigen CD154;[Cleaved into: CD40 ligand,membrane form;CD40 ligand,soluble form]
| 别名 | CD40LG;CD40L;TNFSF5;TRAP;CD40 ligand;CD40-L;T-cell antigen Gp39;TNF-related activation protein;TRAP;Tumor necrosis factor ligand superfamily member 5;CD antigen CD154;[Cleaved into: CD40 ligand,membrane form;CD40 ligand,soluble form] |
| 基因名称 | CD40LG |
| 蛋白名称 | CD40 ligand |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P29965 |
| Mouse Gene ID | 21947 |
| Mouse Swissprot No. | P27548 |
| Rat Gene ID | 84349 |
| Rat Swissprot No. | Q9Z2V2 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 38kDa |
| 预测分子量 | 29kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | disease:Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM) . HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections , including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin , the overall prognosis is rather poor , with a death rate of about 10% before adolescence. ,function:Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. ,function:Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa , actin polymerization , and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. ,online information:CD40L defect database ,PTM:N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. ,PTM:Not O-glycosylated. ,PTM:The soluble form derives from the membrane form by proteolytic processing. ,similarity:Belongs to the tumor necrosis factor family. ,subunit:Homotrimer. ,tissue specificity:Specifically expressed on activated CD4+ T-lymphocytes. , |
| 细胞定位 | Cell membrane ; Single-pass type II membrane protein . Cell surface .; [CD40 ligand , soluble form]: Secreted . Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa , actin polymerization , and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane ; Single-pass type II membrane protein . Cell surface .; [CD40 ligand , soluble form]: Secreted . Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa , actin polymerization , and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. . |
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