货号：GZ9809
CAMKK2;CAMKKB;KIAA0787;Calcium/calmodulin-dependent protein kinase kinase 2;CaM-KK 2;CaM-kinase kinase 2;CaMKK 2;Calcium/calmodulin-dependent protein kinase kinase beta;CaM-KK beta;CaM-kinase kinase beta;CaMKK beta
| 别名 | CAMKK2;CAMKKB;KIAA0787;Calcium/calmodulin-dependent protein kinase kinase 2;CaM-KK 2;CaM-kinase kinase 2;CaMKK 2;Calcium/calmodulin-dependent protein kinase kinase beta;CaM-KK beta;CaM-kinase kinase beta;CaMKK beta |
| 基因名称 | CAMKK2 |
| 蛋白名称 | Calcium/calmodulin-dependent protein kinase kinase 2 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q96RR4 |
| Mouse Gene ID | 207565 |
| Mouse Swissprot No. | Q8C078 |
| Rat Gene ID | 83506 |
| Rat Swissprot No. | O88831 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 60-70kDa |
| 预测分子量 | 65kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The product of this gene belongs to the Serine/Threonine protein kinase family , and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK) . This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory , neuronal differentiation and migration , neurite outgrowth , and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq , Jul 2012] , |
| 细胞定位 | Nucleus . Cytoplasm . Cell projection , neuron projection . Predominantly nuclear in unstimulated cells , relocalizes into cytoplasm and neurites after forskolin induction. . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Nucleus . Cytoplasm . Cell projection , neuron projection . Predominantly nuclear in unstimulated cells , relocalizes into cytoplasm and neurites after forskolin induction. . |
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