| 别名 | ATG4B;APG4B;AUTL1;KIAA0943;Cysteine protease ATG4B;AUT-like 1 cysteine endopeptidase;Autophagin-1;Autophagy-related cysteine endopeptidase 1;Autophagy-related protein 4 homolog B;hAPG4B |
| 基因名称 | ATG4B |
| 蛋白名称 | Cysteine protease ATG4B |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q9Y4P1 |
| Mouse Gene ID | 66615 |
| Mouse Swissprot No. | Q8BGE6 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 44kDa |
| 预测分子量 | 44kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation , metamorphosis , non-apoptotic cell death , and aging. Reduced levels of autophagy have been described in some malignant tumors , and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants , encoding different isoforms , have been characterized. [provided by RefSeq , Jul 2008] , |
| 细胞定位 | Cytoplasm . Cytoplasm , cytosol . Cytoplasmic vesicle , autophagosome . Endoplasmic reticulum . Mitochondrion . Mainly localizes to the cytoplasm , including cytosol (PubMed:29165041) . A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041) . . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm . Cytoplasm , cytosol . Cytoplasmic vesicle , autophagosome . Endoplasmic reticulum . Mitochondrion . Mainly localizes to the cytoplasm , including cytosol (PubMed:29165041) . A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041) . . |
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