| 别名 | SLC3A2;MDU1;4F2 cell-surface antigen heavy chain;4F2hc;4F2 heavy chain antigen;Lymphocyte activation antigen 4F2 large subunit;CD98 |
| 基因名称 | SLC3A2 |
| 蛋白名称 | 4F2 cell-surface antigen heavy chain |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P08195 |
| Mouse Gene ID | 17254 |
| Mouse Swissprot No. | P10852 |
| Rat Gene ID | 50567 |
| Rat Swissprot No. | Q794F9 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:500-1:2000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 68kDa |
| 预测分子量 | 68kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene is a member of the solute carrier family and encodes a cell surface , transmembrane protein. The protein exists as the heavy chain of a heterodimer , covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants , encoding different isoforms , have been characterized. [provided by RefSeq , Nov 2010] , |
| 细胞定位 | Apical cell membrane . Cell membrane ; Single-pass type II membrane protein . Cell junction . Lysosome membrane . Melanosome . Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:9751058 , PubMed:11311135) . Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812) . Recruited to lysosomes by LAPTM4B (PubMed:25998567) . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Located selectively at cell-cell adhesion sites (By similarity) . Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity) . . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Apical cell membrane . Cell membrane ; Single-pass type II membrane protein . Cell junction . Lysosome membrane . Melanosome . Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:9751058 , PubMed:11311135) . Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812) . Recruited to lysosomes by LAPTM4B (PubMed:25998567) . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Located selectively at cell-cell adhesion sites (By similarity) . Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity) . . |
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