| 别名 | GRM2;GPRC1B;MGLUR2;Metabotropic glutamate receptor 2;mGluR2 |
| 基因名称 | GRM2 |
| 蛋白名称 | Metabotropic glutamate receptor 2 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q14416 |
| Mouse Gene ID | 108068 |
| Mouse Swissprot No. | Q14BI2 |
| Rat Gene ID | 24415 |
| Rat Swissprot No. | P31421 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | ＞200kDa |
| 预测分子量 | 99kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | glutamate metabotropic receptor 2 (GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors , that have been divided into 3 groups on the basis of sequence homology , putative signal transduction mechanisms , and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4 , GRM6 , GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Cell junction , synapse . Cell projection , dendrite . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Cell junction , synapse . Cell projection , dendrite . |
周一至周日 8:00-18:00
