| 别名 | PTCH1;PTCH;Protein patched homolog 1;PTC;PTC1 |
| 基因名称 | PTCH1 |
| 蛋白名称 | Protein patched homolog 1 |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q13635 |
| Mouse Gene ID | 19206 |
| Mouse Swissprot No. | Q61115 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 180-210kDa |
| 预测分子量 | 161kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog , a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis , as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome , esophageal squamous cell carcinoma , trichoepitheliomas , transitional cell carcinomas of the bladder , as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described , but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq , Jul 2008] , |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . |
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