| 别名 | BIN1;AMPHL;Myc box-dependent-interacting protein 1;Amphiphysin II;Amphiphysin-like protein;Box-dependent myc-interacting protein 1;Bridging integrator 1 |
| 基因名称 | BIN1 |
| 蛋白名称 | Myc box-dependent-interacting protein 1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | O00499 |
| Mouse Gene ID | 30948 |
| Mouse Swissprot No. | O08539 |
| Rat Gene ID | 117028 |
| Rat Swissprot No. | O08839 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:100-1:500;WB 1:500-1:2000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 55-70kDa |
| 预测分子量 | 65kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes several isoforms of a nucleocytoplasmic adaptor protein , one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin , synaptojanin , endophilin , and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq , Mar 2016] , |
| 细胞定位 | [Isoform BIN1]: Nucleus . Cytoplasm . Endosome . Cell membrane , sarcolemma , T-tubule .; [Isoform IIA]: Cytoplasm . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | [Isoform BIN1]: Nucleus . Cytoplasm . Endosome . Cell membrane , sarcolemma , T-tubule .; [Isoform IIA]: Cytoplasm . |
周一至周日 8:00-18:00
