| 别名 | MCP;MIC10 |
| 基因名称 | CD46 |
| 蛋白名称 | Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46) |
| 推荐应用 | |
| 反应物种 | Human,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P15529 |
| Mouse Swissprot No. | O88174 |
| Rat Swissprot No. | Q9Z0M4 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 55-70kDa |
| 预测分子量 | 44kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I , which protects the host cell from damage by complement. In addition , the encoded protein can act as a receptor for the Edmonston strain of measles virus , human herpesvirus-6 , and type IV pili of pathogenic Neisseria. Finally , the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq , Jun 2010] , |
| 细胞定位 | Cytoplasmic vesicle , secretory vesicle , acrosome inner membrane ; Single-pass type I membrane protein . Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus , Herpesvirus 6 or Neisseria gonorrhoeae , which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria , shedding leads to a soluble peptide. |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasmic vesicle , secretory vesicle , acrosome inner membrane ; Single-pass type I membrane protein . Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus , Herpesvirus 6 or Neisseria gonorrhoeae , which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria , shedding leads to a soluble peptide. |
周一至周日 8:00-18:00
