货号：GZ9708
ILF3;DRBF;MPHOSPH4;NF90;Interleukin enhancer-binding factor 3;Double-stranded RNA-binding protein 76;DRBP76;M-phase phosphoprotein 4;MPP4;Nuclear factor associated with dsRNA;NFAR;Nuclear factor of activated T-cells 90 kDa;NF-AT-90;Translational control protein 80;TCP80
| 别名 | ILF3;DRBF;MPHOSPH4;NF90;Interleukin enhancer-binding factor 3;Double-stranded RNA-binding protein 76;DRBP76;M-phase phosphoprotein 4;MPP4;Nuclear factor associated with dsRNA;NFAR;Nuclear factor of activated T-cells 90 kDa;NF-AT-90;Translational control protein 80;TCP80 |
| 基因名称 | ILF3 |
| 蛋白名称 | Interleukin enhancer-binding factor 3 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q12906 |
| Mouse Gene ID | 16201 |
| Mouse Swissprot No. | Q9Z1X4 |
| Rat Gene ID | 84472 |
| Rat Swissprot No. | Q9JIL3 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 85,110kDa |
| 预测分子量 | 95kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins , dsRNAs , small noncoding RNAs , and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90 , ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45 , ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth , possibly by inhibition of mRNA stabilization. In contrast , an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq , Dec 2014] , |
| 细胞定位 | Nucleus , nucleolus . Cytoplasm . Nucleus . Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Nucleus , nucleolus . Cytoplasm . Nucleus . Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. . |
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