| 别名 | CUL2;Cullin-2;CUL-2 |
| 基因名称 | CUL2 |
| 蛋白名称 | Cullin-2 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q13617 |
| Mouse Gene ID | 71745 |
| Mouse Swissprot No. | Q9D4H8 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:5000-1:20000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 85-90kDa |
| 预测分子量 | 87kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | function:Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes , which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity) . The functional specificity of the ECS complex depends on the substrate recognition component. ECS (VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) . ,pathway:Protein modification; protein ubiquitination. ,PTM:CBC (VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. ,similarity:Belongs to the cullin family. ,subunit:Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL2 , Elongin BC (TCEB1 and TCEB2) , RBX1 and a variable substrate-specific adapter. Component of the ECS (VHL) or CBC (VHL) complex containing VHL. Component of the ECS (MED8) complex with the probable substrate recognition component MED8 (By similarity) . Component of the ECS (PPIL5) complex with the probable substrate recognition component PPIL5. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2 , RBX1 , TCEB1 , TCEB2 and FEM1B. Part of an E3 ubiquitin-protein ligase complex including ZYG11B , CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase complex including ZYG11BL , CUL2 and Elongin BC.Interacts with RBX1 , RNF7 , FEM1B and TIP120A/CAND1. Interacts with COPS2 , and MED8 (By similarity) . Interacts with human respiratory syncytial virus (HRSV) protein NS1. , |
| 细胞定位 | nucleoplasm ,nucleolus ,cytosol ,VCB complex ,cullin-RING ubiquitin ligase complex ,Cul2-RING ubiquitin ligase complex , |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | nucleoplasm ,nucleolus ,cytosol ,VCB complex ,cullin-RING ubiquitin ligase complex ,Cul2-RING ubiquitin ligase complex , |
周一至周日 8:00-18:00
