| 别名 | ATG9 autophagy related 9 homolog A;S. cerevisiae;APG9L1 |
| 基因名称 | ATG9A |
| 蛋白名称 | Atg9a |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q7Z3C6 |
| Mouse Swissprot No. | Q68FE2 |
| Rat Swissprot No. | Q5FWU3 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:10000-1:50000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 100-110kDa |
| 预测分子量 | 94kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | function:Plays a role in autophagy. ,similarity:Belongs to the ATG9 family. , |
| 细胞定位 | Preautophagosomal structure membrane ; Multi-pass membrane protein . Cytoplasmic vesicle , autophagosome membrane ; Multi-pass membrane protein . Golgi apparatus , trans-Golgi network membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein . Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking (PubMed:27316455 , PubMed:27663665) . Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427 , PubMed:30262884) . Under amino acid starvation or rapamycin treatment , redistributes to preautophagosomal structure/phagophore assembly site (PAS) (PubMed:16940348) . The starvation-induced redistribution depends on ULK1 , ATG13 , as well as SH3GLB1 (PubMed:16940348) . Upon autophagy induction , a small portion transiently localizes to the autophagic membranes (PubMed:22456507) . Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599) . . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Preautophagosomal structure membrane ; Multi-pass membrane protein . Cytoplasmic vesicle , autophagosome membrane ; Multi-pass membrane protein . Golgi apparatus , trans-Golgi network membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein . Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking (PubMed:27316455 , PubMed:27663665) . Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427 , PubMed:30262884) . Under amino acid starvation or rapamycin treatment , redistributes to preautophagosomal structure/phagophore assembly site (PAS) (PubMed:16940348) . The starvation-induced redistribution depends on ULK1 , ATG13 , as well as SH3GLB1 (PubMed:16940348) . Upon autophagy induction , a small portion transiently localizes to the autophagic membranes (PubMed:22456507) . Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599) . . |
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