| 别名 | RRAGA;Ras-related GTP-binding protein A;Rag A;RagA;Adenovirus E3 14.7 kDa-interacting protein 1;FIP-1;RRAGB;Ras-related GTP-binding protein B;Rag B;RagB |
| 基因名称 | RRAGA/RRAGB |
| 蛋白名称 | Ras-related GTP-binding protein A/B |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q7L523;Q5VZM2 |
| Mouse Gene ID | 68441;245670 |
| Rat Gene ID | 117044;100909655 |
| Rat Swissprot No. | Q63486;Q63487 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:500;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 30,37kDa |
| 预测分子量 | 37kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | function:Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K , an inhibitor of TNF-alpha functions , thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. ,similarity:Belongs to the GTR/RAG GTP-binding protein family. ,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus , depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. ,subunit:Can occur as a homodimer , or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. ,tissue specificity:Ubiquitously expressed with highest levels of expression in skeletal muscle , heart , and brain. , |
| 细胞定位 | Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus , depending on the bound nucleotide state (PubMed:8995684 , PubMed:9394008) . Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684) . . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus , depending on the bound nucleotide state (PubMed:8995684 , PubMed:9394008) . Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684) . . |
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