| 别名 | DKC1;NOLA4;H/ACA ribonucleoprotein complex subunit 4;CBF5 homolog;Dyskerin;Nopp140-associated protein of 57 kDa;Nucleolar protein NAP57;Nucleolar protein family A member 4;snoRNP protein DKC1 |
| 基因名称 | DKC1 |
| 蛋白名称 | H/ACA ribonucleoprotein complex subunit 4 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | O60832 |
| Mouse Gene ID | 245474 |
| Mouse Swissprot No. | Q9ESX5 |
| Rat Gene ID | 170944 |
| Rat Swissprot No. | P40615 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 58kDa |
| 预测分子量 | 58kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | dyskerin pseudouridine synthase 1 (DKC1) Homo sapiens This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance , as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs) . This gene is highly conserved and widely expressed , and may play additional roles in nucleo-cytoplasmic shuttling , DNA damage response , and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Jan 2014] , |
| 细胞定位 | [Isoform 1]: Nucleus , nucleolus . Nucleus , Cajal body . Also localized to Cajal bodies (coiled bodies) . .; [Isoform 3]: Cytoplasm . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | [Isoform 1]: Nucleus , nucleolus . Nucleus , Cajal body . Also localized to Cajal bodies (coiled bodies) . .; [Isoform 3]: Cytoplasm . |
周一至周日 8:00-18:00
