| 别名 | CYP2C19;Cytochrome P450 2C19;R;-limonene 6-monooxygenase;S;-limonene 6-monooxygenase;S;-limonene 7-monooxygenase;CYPIIC17;CYPIIC19;Cytochrome P450-11A;Cytochrome P450-254C;Mephenytoin 4-hydroxylase |
| 基因名称 | CYP2C19 |
| 蛋白名称 | Cytochrome P450 2C19 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P33261 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 56kDa |
| 预测分子量 | 56kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | cytochrome P450 family 2 subfamily C member 19 (CYP2C19) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol , steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics , including the anticonvulsive drug mephenytoin , omeprazole , diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin , known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq , Jul 2008] , |
| 细胞定位 | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
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