| 基因名称 | PCBP2 |
| 蛋白名称 | Poly (rC) -binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q15366 |
| Mouse Swissprot No. | Q61990 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:500;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 40-45kDa |
| 预测分子量 | 39kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK , it is one of the major cellular poly (rC) -binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1 , this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES , promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA , human papillomavirus type 16 L2 mRNA , and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate |
| 细胞定位 | Nucleus . Cytoplasm . Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Nucleus . Cytoplasm . Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. |
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