| 别名 | PSEN2;AD4;PS2;PSNL2;STM2;Presenilin-2;PS-2;AD3LP;AD5;E5-1;STM-2;[Cleaved into: Presenilin-2 NTF subunit;Presenilin-2 CTF subunit] |
| 基因名称 | PSEN2 |
| 蛋白名称 | Presenilin-2 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P49810 |
| Mouse Gene ID | 19165 |
| Mouse Swissprot No. | Q61144 |
| Rat Gene ID | 81751 |
| Rat Swissprot No. | O88777 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200 |
| 参考分子量 | 23 (C-terminal fragment),54 (full-length)kDa |
| 预测分子量 | 50kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase , an enzyme that cleaves APP. Also , it is thought that the presenilins are involved in the cleavage of the Notch receptor such that , they either directly regulate gamma-secretase activity , or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq , Jul 2008] , |
| 细胞定位 | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . |
周一至周日 8:00-18:00
