| 别名 | DRD3;D;3;dopamine receptor;Dopamine D3 receptor |
| 基因名称 | DRD3 |
| 蛋白名称 | D (3) dopamine receptor |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P35462 |
| Mouse Gene ID | 13490 |
| Mouse Swissprot No. | P30728 |
| Rat Gene ID | 29238 |
| Rat Swissprot No. | P19020 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 48kDa |
| 预测分子量 | 44kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain , which are associated with cognitive , emotional , and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms , although some variants may be subject to nonsense-mediated decay (NMD) . [provided by RefSeq , Jul 2008] , |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes) , followed by the dispersal of the receptors to the membrane (30 minutes) . DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes) , followed by the dispersal of the receptors to the membrane (30 minutes) . DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. |
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