货号：GZ9623
Cyclic AMP-responsive element-binding protein 3;CREB-3;cAMP-responsive element-binding protein 3;Leucin zipper proitein;Luman;Transcription factor LZIP-alpha;[Cleaved into: Processed cyclic AMP-responsive element-binding protein 3;N-terminal Luman;Transcriptionally active form;]
| 别名 | Cyclic AMP-responsive element-binding protein 3;CREB-3;cAMP-responsive element-binding protein 3;Leucin zipper proitein;Luman;Transcription factor LZIP-alpha;[Cleaved into: Processed cyclic AMP-responsive element-binding protein 3;N-terminal Luman;Transcriptionally active form;] |
| 基因名称 | CREB3 |
| 蛋白名称 | CREB3 |
| 推荐应用 | |
| 反应物种 | Human,Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | O43889 |
| Mouse Swissprot No. | Q61817 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000 |
| 参考分子量 | 44kDa |
| 预测分子量 | 41kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1 , which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration , tumor suppression , and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified , but their biological validity has not been determined.[provided by RefSeq , Nov 2009] , |
| 细胞定位 | [Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus . Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756) . Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900) . Colocalizes with CANX , CCR1 , HCFC1 in the ER membrane (PubMed:10623756) . .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly in the nucleus (PubMed:19779205) . Not associated with membranes (PubMed:19779205) . .; [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB) . .; [Isoform 1]: Cytoplasm. (Microbial infection) Sequestered into the cytoplasm by the HCV core protein. . |
| 纯化 | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Clonality | Monoclonal |
| 细胞定位 | [Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus . Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756) . Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900) . Colocalizes with CANX , CCR1 , HCFC1 in the ER membrane (PubMed:10623756) . .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly in the nucleus (PubMed:19779205) . Not associated with membranes (PubMed:19779205) . .; [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB) . .; [Isoform 1]: Cytoplasm. (Microbial infection) Sequestered into the cytoplasm by the HCV core protein. . |
周一至周日 8:00-18:00