货号：GZ9600
CASP1;IL1BC;IL1BCE;Caspase-1;CASP-1;Interleukin-1 beta convertase;IL-1BC;Interleukin-1 beta-converting enzyme;ICE;IL-1 beta-converting enzyme;p45;[Cleaved into: Caspase-1 subunit p20;Caspase-1 subunit p10]
| 别名 | CASP1;IL1BC;IL1BCE;Caspase-1;CASP-1;Interleukin-1 beta convertase;IL-1BC;Interleukin-1 beta-converting enzyme;ICE;IL-1 beta-converting enzyme;p45;[Cleaved into: Caspase-1 subunit p20;Caspase-1 subunit p10] |
| 基因名称 | CASP1 |
| 蛋白名称 | Caspase-1 |
| 推荐应用 | |
| 反应物种 | Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P29466 |
| Mouse Gene ID | 12362 |
| Mouse Swissprot No. | P29452 |
| Rat Swissprot No. | P43527 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:100-1:200;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 22kDa |
| 预测分子量 | 45kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012], |
| 细胞定位 | Cytoplasm . Cell membrane . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm . Cell membrane . |
周一至周日 8:00-18:00