| 别名 | DPYD;Dihydropyrimidine dehydrogenase [NADP;+;];DHPDHase;DPD;Dihydrothymine dehydrogenase;Dihydrouracil dehydrogenase |
| 基因名称 | DPYD |
| 蛋白名称 | Dihydropyrimidine dehydrogenase [NADP(+)] |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q12882 |
| Mouse Gene ID | 99586 |
| Mouse Swissprot No. | Q8CHR6 |
| Rat Gene ID | 81656 |
| Rat Swissprot No. | O89000 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 111kDa |
| 预测分子量 | 111kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009], |
| 细胞定位 | Cytoplasm. |
| 功能 | Catalytic activity:5,6-dihydrouracil + NADP(+) = uracil + NADPH.,cofactor:Binds 2 4Fe-4S clusters. Contains approximately 33 iron atoms per molecule.,cofactor:Binds 2 FAD.,cofactor:Binds 2 FMN.,Disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.,Function:Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.,pathway:Amino-acid biosynthesis; beta-alanine biosynthesis.,similarity:Belongs to the dihydropyrimidine dehydrogenase family.,similarity:Contains 3 4Fe-4S ferredoxin-type domains.,subunit:Homodimer.,tissue specificity:Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells., |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm. |
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